What You Need to Know About Magnesium for Depression and Anxiety

By Jonathan Hunsaker

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Do you worry about things constantly? Does persistent stress keep you from relaxing, even at the end of your workday? Do you have trouble falling or staying asleep? If so, then you could be suffering from anxiety that, if left to run its course, could end up snowballing into a lifetime of chronic illness.

Roughly 40 million Americans suffer from anxiety disorders that, in many cases, started off as routine bouts of stress and anxiety that were shrugged off as being part of life. Consequently, it piled on to the point of inducing panic attacks, obsessive-compulsive disorder (OCD), and even post-traumatic stress disorder (PTSD) [1].

The medical establishment offers pharmaceutical medications and psychotherapy as solutions, but what if the root cause of many cases of depression and anxiety is a mineral deficiency? What if something as simple as consuming more magnesium helped to take the edge off and gave you some daily peace of mind? In this article, we’re exploring some of the research into and the benefits of magnesium for depression and anxiety.

As Magnesium Deficiency Has Increased, So Has Chronic Illness

An increasing volume of research is pointing to magnesium deficiency as the culprit behind a wide range of health problems. The majority of people living in America and Europe are now deficient in magnesium, and the statistics on rising levels of chronic illness all throughout the West reflect that.

More than 600 critical chemical reactions throughout the body require magnesium [2], including:

  • energy creation
  • protein formation
  • gene maintenance
  • muscle movements
  • nervous system regulation

And yet most people don’t get nearly enough magnesium from diet alone. Depending on what you eat and how active you are, you could be slightly in the red or deeply deficient in this life-supporting mineral.

Even people who think they’re healthy may not be getting enough magnesium due to chemical exposure, depleted growing soils, and heavy food processing.

Decreasing Magnesium Levels in Food

Refined wheat, for example, only contains about 16% of the original amount of magnesium compared to whole wheat [3]. Many other foods are just as bad or worse, including foods that would otherwise be healthy were it not for various environmental factors that deplete their mineral stores.

Consequently, average magnesium consumption dropped from about 450 milligrams per day in the 19th century and prior to 250 mg or less per day in the 20th and early 21st centuries.

Athletes Need More Magnesium


If you exercise regularly, you could be even more deficient as athletes require an additional 10-20% more magnesium just to keep up with the baseline levels of everybody else.

Only you know your own body, but if you constantly feel sluggish, worried, stressed, or depressed – especially for no obvious reason – this could be your body telling you that you need more magnesium for anxiety to calm your nervous system, feed your brain, and promote overall feelings of balance, calm, and wellbeing.

Mood Disorders Were Rare in the Early 1900s

Consider the fact that people born around 1900 rarely experienced depression, either in childhood or adulthood. The depression rate was barely one percent.

In 1935, however, it jumped to one percent by the time a person reached 15 years old, and two percent by the time they reached 25. By the age of 45, a comparatively whopping nine percent of those born in 1935 were determined to suffer from depression.


Depression Rates Jumped to 25% by 1955

These figures all respectively increased for those born in 1955, with six percent of people in this demographic developing depression by the age of 25, and 25% of people born in 1955 developing it at some point throughout the course of their lives.

Depression Today Is a Global Issue

Today, nearly half of all people will develop a depressive disorder, a massive increase that directly corresponds to ever-increasing rates of magnesium deficiency, which is rapidly becoming a global problem.

“Approximately 68% of U.S. adults consume less than the U.S. recommended daily allowance (RDA) of Mg (420 mg / day for men, 320 mg / day for women), with 19% consuming less than half of the RDA,” warned one research study looking into magnesium for depression and anxiety in adults back in 2009 [4].

Signs & Symptoms of Depression

Depression isn’t just feeling sad all the time. The core symptoms of depression include:

  • lack of energy
  • increased or decreased appetite
  • weight and sleep disturbances (difficulty falling asleep or staying asleep, early morning awakening, and melancholic depression)

On the emotional side, symptoms may include:

  • easy agitation
  • sadness
  • unresponsiveness (feelings of “feelinglessness”)
  • erratic behavior
  • unfounded guilt
  • suicidal thoughts

Since the human brain is fueled by magnesium, it makes sense that a lack of it could lead to mood swings, “brain fog,” and over time much more severe health problems if the deficiency persists [5,6].

Science has pegged the lack of magnesium as one of the major contributors to widespread mental illness and other health problems [7].

Depression & Anxiety Are Neuropsychiatric Disorders

Neuropsychiatric disorders (which include depression and anxiety) now account for 36% of all non-communicable illnesses. They are also the leading cause of all disabilities – more than twice that of cardiovascular diseases and cancer – in both the U.S. and Canada.

If you’re not familiar with the terminology, neuropsychiatric disorder is an umbrella term for a wide range of conditions that affect neurology (the nervous system) and psychology. This includes:

  • certain types of addiction
  • eating disorders
  • palsies
  • seizures
  • migraine headaches
  • unfiltered anger
  • attention deficits
  • cognitive deficits
  • anxiety and depression

In addition to anxiety and depression, correcting a magnesium deficiency has shown to be helpful with other neuropsychiatric disorders including migraine headaches [8] and ADHD [9].

Most Cases of Major Depression Are Resistant to Drug-Based Treatments

The unfortunate reality of treating mental disorders (including anxiety and depression), is that drugs often don’t work and can actually make things worse in some cases. Studies have found that most cases of major depression (MD) are actually resistant to drug-based treatments anyway, a pathology that’s officially known as treatment-resistant depression [10].

mature-woman-in-consultation-with-female-doctor-sitting-on-examination-table-in doctors-office

Some antidepressant drugs have been shown to provide minimal benefits, but this may be simply because they work to increase magnesium levels in the brain. In other words, magnesium is the active ingredient in the remedy, while said drugs merely act as delivery vehicles to get that magnesium to where it needs to be.

Since there is no pharmaceutical in existence that is free from side effects, it may be worth exploring with your doctor if magnesium supplementation is beneficial for addressing your anxiety or depression.

Magnesium Deficiency Linked to Other Brain & Nervous System Issues

As it turns out, many of the risk factors for depression directly overlap with symptoms of magnesium deficiency. These include things like:

  • low systolic blood pressure
  • reduced heart rate variability (HVR)
  • insomnia
  • elevated inflammatory markers like plasma interleukin g (IL-6), TNFα, and prostaglandin E2 (PDE2)

Magnesium deficiency that leads to psychological pathologies can also trigger pathophysiologic mechanisms such as:

  • increased stress hormone axis (HPA-axis)
  • higher density of rapid eye movements during sleep
  • less slow-wave sleep (SWS), particularly during the first sleep cycle

Magnesium deficiency also causes calcium channels coupled with N-methyl-D-aspartate (NMDA) to bias towards opening, which in turn causes neuronal injury and neurological dysfunction. This explains why anti-inflammatory substances like TNFα-antagonists, cyclooxygenase inhibition, and omega-3 fatty acids have been shown in studies to also produce antidepressant effects.


All that to say if magnesium is lacking, the brain and nervous system can end up going haywire. The good news is that introducing more magnesium through diet and/or supplementation has been shown to produce the opposite effect.

Studies Show Magnesium Can Reduce Feelings of Stress & Improve Mood

One of the first studies on magnesium treatment ever published for agitated depression back in 1921 found that 88% of those who received it had successful outcomes. More recently, a randomized controlled trial found that older adults with type 2 diabetes who took 450mg of magnesium daily improved their mood to the same degree or better than if they took an antidepressant pharmaceutical [11].

Another study that looked at athletes who took magnesium for four weeks found that they experienced dramatic improvements in their ability to run, cycle, and swim during a triathlon. More importantly in terms of brain health, these athletes saw notable decreases in levels of insulin and the stress hormone cortisol, resulting in decreased stress and anxiety [12].

What Is the Best Magnesium for Anxiety and Depression?


While more people (including those with anxiety and depression) are becoming aware of the magnesium deficiency epidemic, many of them are confused about how to correct it – especially when there are so many choices out there for magnesium supplements.

As you might expect, not all magnesium supplements are created equal. Many use cheap forms of magnesium that are lacking in bioavailability, while others fail to cover the full spectrum of what magnesium in its different forms has to offer.

Organic vs Inorganic Magnesium

There are two major types of elemental magnesium salts available: organic and inorganic.

Inorganic salts of magnesium include:

  • magnesium oxide (the main ingredient in milk of magnesia)
  • magnesium chloride
  • magnesium hydroxide
  • magnesium sulfate (Epsom salt)

Inorganic magnesium salts contain higher concentrations of magnesium, but they are much more difficult for the body to absorb. For example, the body is only able to absorb around 4% of magnesium oxide taken by mouth [13].

Man holding toilet paper roll in bathroom

Magnesium oxide is also more likely to cause diarrhea. Because less of it is absorbed into the body, it leaves more magnesium in the intestine to act as a laxative. This laxative effect is beneficial if you’re constipated, but likely not desirable the rest of the time!

Organic salts have much higher bioavailability. When looking for a quality magnesium supplement, here are some of the best types available.

7 of the Best Types of Magnesium for Bioavailability (Absorption)

1. Magnesium Citrate

Bound with citric acid, this type of magnesium is found naturally in citrus fruits. It’s what gives them their tart, sour flavor. Magnesium citrate is relatively easy to find and highly bioavailable [14].

Taking magnesium citrate for anxiety is a popular natural remedy. It’s also used by people who suffer from constipation as it produces a laxative effect. Magnesium citrate also works as a calming agent to support a healthy mood and relaxation [15].

2. Magnesium Glycinate

Formed by combining elemental magnesium with the amino acid glycine, magnesium glycinate is found in many protein-rich foods such as meat, dairy, fish, and legumes. Like magnesium citrate, it’s easily absorbed and produces a calming effect.

It is commonly sold as a standalone supplement to support healthy inflammation levels and promote rest [16].

3. Magnesium Aspartate

A common ingredient in the muscle-building formula ZMA (zinc magnesium aspartate), magnesium aspartate may be useful for energy generation, muscle creation, and nerve function.


When combined with zinc and vitamin B6, evidence suggests that magnesium aspartate could aid in hormone balance, exercise recovery, healthy sleep, muscle support, and increased strength.

Made by chelating aspartate, magnesium aspartate is also beneficial for supporting a healthy acid-alkaline balance in the body. It has also been shown to reduce insulin resistance in overweight people with otherwise normal levels of serum and intracellular magnesium [17].

4. Magnesium Malate

When combined with malic acid, magnesium becomes magnesium malate, one of the most highly bioavailable forms of magnesium available [18]. Many people use magnesium malate for depression, migraines, and chronic pain. It also functions as a laxative to promote regular, healthy bowel movements, as well as an antacid for heartburn and an upset stomach [19].

5. Magnesium Orotate

The orotate component of magnesium orotate is a critical component in the construction of bodily genetic material such as DNA [20]. Unlike many of the other forms of magnesium out there, orotate does not produce a strong laxative effect, though it is highly bioavailable.

Its orotic acid component plays a unique role in supporting the energy production pathways found in heart and blood vessel tissue, making it popular among competitive athletes and fitness enthusiasts. Magnesium orotate may also help people with heart disease.


One study that looked at people with congestive heart failure who took magnesium orotate supplements found that it helped to improve symptom management and survival outcomes better than a placebo. The only downside is that magnesium orotate is generally more expensive than other forms of magnesium.

6. Magnesium Taurate

Made with the amino acid taurine, magnesium taurate is perhaps most known for the role it plays in regulating blood sugar, as well as blood pressure, making it a powerful heart health nutrient.

7. Magnesium Amino Acid Chelate

Derived from the Greek word for “claw,” chelate refers to the combining of organic compounds with inorganic compounds for the purpose of improving bodily uptake of a nutrient. The belief is that chelates bypass the normal digestive process, meaning minerals (in this case magnesium) are deposited directly into the body without having to be processed through the gut.

As you might guess by its name, magnesium amino acid chelate is magnesium bound to amino acids – the building blocks of protein. Another common term for magnesium amino acid chelate is simply “magnesium chelate.”

Some believe magnesium chelate to be the “purest” form of magnesium because its complete ring structure reduces the chance that it will negatively react with fat-soluble vitamins and other minerals in the digestive tract, boosting not only its absorption rate but also its effectiveness.

Recent Research Confirms the Benefit of Magnesium for Depression and Anxiety

Does magnesium help with depression and anxiety? From the available evidence, it appears that magnesium supplementation is well-tolerated and enhances the efficacy of conventional antidepressant treatments.

According to a 2016 review published in the journal Magnesium Research looking into magnesium and depression:

“The mood-improving potential of magnesium compounds have been confirmed by the results of numerous pre-clinical and clinical studies [21].”

A 2017 systematic review examining the effect of magnesium supplementation on subjective anxiety and stress concluded that:

“Existing evidence is suggestive of a beneficial effect of Mg on subjective anxiety in anxiety vulnerable samples [22].”

An even more recent systematic review of the role of magnesium in mental disorders was published in June 2020 in the journal Nutrients. These researchers concluded that “from the available evidence, it emerged that supplementation with magnesium could be beneficial [23].” They also recommended more studies to evaluate the efficacy of magnesium alone and in combination with other drugs (e.g., antidepressants) in order to establish correct use.  

Introducing Organixx Magnesium 7

If you and your doctor have determined that magnesium supplementation is appropriate for you, you might consider a highly bioavailable source of magnesium such as new Magnesium 7 from Organixx.

Magnesium 7 is a premium, broad-spectrum magnesium supplement that includes equal amounts of seven of the best organic types of magnesium. In each 2-capsule serving of Magnesium 7, you get 500 mg of the highest-quality elemental magnesium in “chelated” (bonded) forms for optimal bioavailability.

Magnesium deficiency is linked to stress, diabetes, heart disease, osteoporosis, chronic fatigue syndrome, depression, anxiety, trouble sleeping, sore muscles, migraines, and many more debilitating health conditions.

If your body needs magnesium, you want the most beneficial kind your body can actually absorb. Organixx Magnesium 7 gives you seven (7) of the very best, most bioavailable types of elemental magnesium available.

Magnesium Supplement

Article Summary

  • The majority of Americans and Europeans are deficient in magnesium. An increasing volume of research points to magnesium deficiency as the culprit behind a wide range of health problems.

  • More than 600 critical chemical reactions throughout the body require magnesium, including:

    • energy creation
    • protein formation
    • gene maintenance
    • muscle movements
    • nervous system regulation
  • Science has pegged the lack of magnesium as one of the major contributors to widespread mental illness and other health problems.

  • Studies have found that most cases of major depression (MD) are actually resistant to drug-based treatments.

  • According to a 2016 review published in the journal Magnesium Research looking into magnesium and depression:

    “The mood-improving potential of magnesium compounds have been confirmed by the results of numerous pre-clinical and clinical studies.”

  • Not all magnesium supplements are created equal. Many use cheap forms of magnesium that are lacking in bioavailability.

  • Magnesium 7 from Organixx is a premium, broad-spectrum magnesium supplement that includes equal amounts of seven of the best organic types of magnesium.


    • Hi Doug, thanks for your question & interest.

      Organixx Magnesium 7 supplement does not contain Threonate. It does, however, contain 7 of the best types of magnesium for bioavailability (Absorption).

      1. Magnesium Citrate (Bone Strength)- an essential trace mineral involved in dozens of functions and chemical processes in the body including bone formation, healthy blood sugar management, and metabolism. It’s also a major antioxidant. It's necessary for the proper functioning of the nervous system, the brain, and many key enzymatic reactions in the body. As an antioxidant, it helps to protect cells from the free radical damage that causes aging and diseases such as cancer. It also aids in blood sugar regulation through its role in the synthesis and secretion of insulin. It plays an important role in energy production, metabolism and activates various enzymes for the proper digestion and utilization of food. Can be especially beneficial for strengthening bones.

      2. Magnesium Glycinate (Sleep, Anxiety & Brain Health)- it’s best known for benefits relating to sleep and brain health. It has a soothing effect on the brain and may help calm anxiety. It also helps to soothe pain, including migraines and pain related to PMS. It can promote better sleep, and even assist in stabilizing blood sugar in those with diabetes.

      3. Magnesium Aspartate (Mood, Anxiety & Depression)- often used by bodybuilders to enhance athletic performance, recovery, and muscle strength. Many users report finding this form one of the best magnesium supplements for leg cramps and other muscle cramping. Can also help ease symptoms of acute asthma such as breathlessness. Beneficial for neurological and psychiatric diseases, including depression and anxiety.

      4. Magnesium Malate (Brain & Nervous system)- helps support and improve ATP (adenosine triphosphate) production at a cellular level, which improves energy and helps reduce pain. It's an excellent form of magnesium support for issues relating to depression, sleep, chronic pain, and fatigue, including fibromyalgia and chronic fatigue system (CFS).

      5. Magnesium Orotate (Heart & Exercise Performance)- supports the energy production pathways found in heart and blood vessel tissue, making it popular among competitive athletes and fitness enthusiasts. It may also help people with heart disease.

      6. Magnesium Taurate (High Blood Pressure, Relaxation & "Calming the Nerves”)- vital for a healthy heart, muscles, and bones. It’s essential for maintaining healthy nerve impulses, a healthy heart rhythm, and muscle contraction. It also plays an important role in intestinal health and is the best magnesium supplement for constipation. It helps regulate blood sugar, as well as blood pressure, making it a powerful heart health nutrient.

      7. Magnesium Amino Acid Chelate (Muscle Recovery)- benefits include increased stability and superior bioavailability. This allows for more of the mineral to be effectively utilized by the body for the wide range of health benefits that magnesium confers.

      The seven forms of magnesium in Magnesium 7 represent the very best types of magnesium recommended by leading health experts for addressing a wide range of health concerns.

      With so many different kinds of magnesium supplements to choose from, picking the right one can be problematic. That’s why we’re making the solution easy for you. Magnesium 7 is a premium magnesium complex that serves up seven (7) of the best types of magnesium all in one convenient daily formula. In each 2-capsule serving, you get 500 mg of the highest-quality elemental magnesium in “chelated” (bonded) forms for optimal bioavailability.

      If you would like to learn more, we invite you to check out the product page where you will find product details, ingredient label, FAQs, and more: https://shop.organixx.com/collections/all-products/products/magnesium-7

      We hope you find this information helpful and wish you a lovely day!

    • Hi Bernard. Thank you for being here with us. Unfortunately, we are unable to provide medical advice since we are unfamiliar with each persons specific health situation and tolerance levels. However, generally speaking I have seen information on the internet where others have done so under the advice of a physician. Please consult with your trusted healthcare provider for guidance on this. Wishing you good health and happiness always!

    • Hello Kristy, There is research to support taking magnesium along with anti depressants can be beneficial. However we are unable to provide medical advice. We suggest you direct this question to your trusted physician who will know if this is right for your specific situation. We want you to be safe and healthy. Sunshine has also been known to help with depression. Thank you for being here with us. Enjoy this beautiful day! :)

  1. I am interested but I am in Canada. I tried to order but the address only allowed for US. If Canadian shipping is possible, please let me know.

    • Hi Marcia,

      Thank you for your interest in our Magnesium 7 Supplement.

      We're sorry you're having trouble placing your order. We do ship internationally, including to Canada. If you scroll all the way to the bottom of the article and click on the image of our Magnesium 7 Supplement, it will bring you to the product shop page where you can place your order.

      Alternatively, you can also go here: https://shop.organixx.com/products/magnesium-7

      We hope this helps and wish you a lovely day!

  2. Why did you not put mag threonate in it?? You should reconsider it. All the others are great as well but now I have to add one more pill.

    Cuz my brain and all brains need the threonate.

    • Hi Karen, thanks for your interest.

      Although there is no L-threonate it does include one of the most popular forms of magnesium. Magnesium glycinate (also known as magnesium diglycinate or magnesium bisglycinate) is a chelated form of magnesium that contains the amino acid glycine. Glycine is the smallest amino acid and is able to cross the blood-brain barrier. It’s best known for its benefits relating to sleep and brain health.

      If you’re looking for the best magnesium supplement for anxiety, magnesium glycinate has been shown to have a soothing effect on the brain and several studies have shown that magnesium glycinate may help to calm anxiety. You can find more information here: https://shop.organixx.com/products/magnesium-7

      We hope you find this information helpful and decide to give it a try! Have a wonderful day!

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