Vitamin C and Collagen: What’s the Connection?

By Nikki Lyn Pugh

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You may have heard already about some of the fantastic health benefits of collagen – especially for joint and skin health. Did you know, though, that certain micronutrients can boost your own body’s natural ability to produce and effectively use collagen? It’s true, and one of the most powerful is good old vitamin C.

Read on to learn just why collagen and vitamin C make ideal partners when it comes to improving your health – and beauty – at any age!

Vitamin C and Collagen: How It Works

Collagen is a vital substance made of amino acids (mainly glycine and proline and sometimes others such as lysine) and accounts for the majority of all protein in the body. Its job is the formation of connective tissue in the body: cartilage in joints, internal tissue in organs, fibrous substances in bones, skin tissue, and so much more.human anatomy muscles

Vitamin C is a necessary substance for collagen production in the body. Without it, the body simply cannot produce it. It is needed for collagen storage and synthesis (i.e. how the body absorbs substances and works with other substances for vital functions).

Collagen forms the fibers that “hold together” the body. Likewise, vitamin C is responsible for “holding together” cells during collagen creation [1]. It is the catalyst for a process called hydroxylation (adding hydrogen and oxygen) within the amino acids proline and lysine.

From this, a precursor molecule is created called procollagen within the cell. All of these microscopic steps are needed for collagen to be eventually be created outside of the cell and then go on to eventually form the tissues that hold us all together and that we can see with the naked eye [2].

Not Just a “Vanity Vitamin”

Vitamin C is considered a “vanity vitamin” for what it can do for skin, hair, and nails. We will explore this in the next section. As you shall see, however, vitamin C and collagen work together for the health of many other functions in your body as well.

Vitamin C plays a key role in skin health mainly because it saturates both the dermis (middle) and the epidermis (top) levels of skin. It is transported to the skin through the bloodstream. Transport proteins tuned specifically to vitamin C are found in all layers of the skin, but especially in the epidermis.

The high amounts of vitamin C that exist in the first two layers of skin makes it a photoprotective substance. This means it has the ability to protect the body from too much UV light from the sun. It is an antioxidant as well, so it also reduces damage caused by free radicals. In the early 1980s, natural health pioneer Linus Pauling became the first to study the protective effects of vitamin C against carcinoma in mice [3].

And, of course, vitamin C is essential for collagen production and synthesized in the skin too. The right amount of vitamin C in your diet every day can help collagen do its job by keeping skin hydrated and helping to maintain its elasticity.

A French study published in the International Journal of Cosmetic Science back in 1998 found that an “Exogenous Vit C supply could thus contribute to the maintenance of optimal collagenic density in the dermis and locally strengthen the collagen network [4].” [Note: “Exogenous” refers to something from outside the body.]

Vitamin C and Gut Healing

Vitamin C also plays a vital role in helping form collagen networks in the body which form healthy tissues in internal organs, including the gut. Believe it or not, collagen assists in several functions in your digestive tract:

  • It helps to balance stomach acid by its high glycine content.
  • It helps to keep the digestive tract hydrated through a process called collagen glycation [5].
  • It is thought to aid in the repairing of the stomach and intestines as type I and type III collagen are the “raw materials” for pretty much all connective tissues in the GI tract.Research has also linked higher levels of collagen with helping Irritable Bowel Syndrome (IBS), stomach ulcers, and healing Leaky Gut Syndrome. A study conducted by University Hospital Heraklion in Greece found that patients who had lower serum collagen levels had a higher incidence of IBS than those who had a level more in the normal range [6].While there have been no major studies yet as to the direct connection between collagen levels and Leaky Gut, it would make sense that boosting your collagen levels through increasing vitamin C, taking collagen supplements, or both would help “seal” the gut. After all, the “villi” in the gut (tiny microscopic folds in the intestinal wall) are made of collagen. Leaky Gut has long been connected with many disease conditions, especially autoimmune disorders [7].

Collagen and Vitamin C Supplements

Vitamin C is a water soluble vitamin which means it is not stored in the body. This means that if you want optimal health, you must feed your body plenty of it every day from the foods you consume. This is especially true if you are deficient in collagen as well.

Some foods that are high in vitamin C include:foods high in vitamin C

  • Citrus, including grapefruit, oranges, lemons, and limes,
  • Strawberries,
  • Papaya
  • Broccoli
  • Kale
  • Tomatoes
  • Peppers, such as jalapenos, serranos, and bell peppers
  • Rose hips
  • Acerola cherries
  • Camu camu

Just like with collagen deficiency, when a person suffers from a chronic deficiency of vitamin C or if a person is older, supplementation can be very helpful. And even people consuming a real, whole foods diet can still end up deficient in many vitamins and minerals.

According to a study of 43 garden crops conducted by the University of Texas in Austin, nutrient content across the board has declined significantly in the last five decades [8]. Environmental pollution, soil-depleting farming practices, poor lifestyle habits like smoking, and boatloads of stress all lead to chronic deficiencies of many essential nutrients like vitamin C.

Fortunately, some quality collagen products include vitamin C in their formulas because of the intimate relationship between the two substances. This is the case with Organixx’s Clean Sourced Collagens blend, one of the purest, most well-researched collagen products on the market today.

Organixx Clean Sourced Collagens blend contains five types of collagen from four sources. What’s more, it’s combined with targeted nutrients such as zinc, vitamin C, and vitamin B6 which specifically enhance the bioavailability and potency of collagen. Clean Sourced Collagens is formulated from the ground up to enhance and support your body’s natural ability to heal and rebuild itself from the INSIDE out.

Organixx Clean Sourced Collagens
Nikki Lyn Pugh
Nikki Lyn Pugh, MFA, INHC is a natural health researcher and writer. She is also an integrative nutritional health coach specializing in autoimmune conditions, chronic stress, and energy medicine. She loves to inspire people to become empowered with their health through education and gentle guidance. Nikki lives and works in Cottonwood, AZ, with her bunny "Mr. Dot."

Article Summary

  • Collagen is a vital substance made of amino acids that accounts for the majority of all protein in the body.

  • Its job is the formation of connective tissue in the body: cartilage in joints, internal tissue in organs, fibrous substances in bones, skin tissue, and so much more.

  • The bad news is that collagen production tends to wane with age. Vitamin C is a necessary substance for collagen production in the body. Without it, the body simply cannot produce it.

  • Both low collagen and low vitamin C input can lead to saggy skin, wrinkles, heart issues, Leaky Gut, and chronic disease.

  • Vitamin C is a water soluble vitamin which means it is not stored in the body. You must feed your body vitamin C daily from the foods you consume.

  • If you are taking a collagen supplement, ensure your body is getting enough vitamin C to benefit from it. Organixx Clean Sourced Collagens contains vitamin C from natural (not synthetic) sources.


  1. Hi

    I am taking collagen and it is the skinny fit Product , but it does not have Vitamin C in it. can i mix the vit c in it , will i get the same effect from the collagen , I was talking a friend of mine and he is a doctor and he is very Knowledgeable on this stuff, can u help me on this one, Or do i need to take the collagen that has the vitamin C in it .. I eat oranges and i believe that has v C, but i main Question is Do i have to take the collagen with the Vit C directly in it, or can i add it too my collagen in a power ..

    • Thank you for your questions, Joanne.

      Unfortunately, we cannot give advice on the suggested usage of other brand's collagen products. With this, you will need to reach out to them or have a consultation with a trusted medical specialist to help you determine if you will need to take Vitamin C in addition to their collagen supplement.

      With this, we'd like to share how our very own Clean Sourced Collagens contain Vitamin C is from the amazing source of Acerola Chery and Camu Camu. This means that taking the Organixx Collagens will not require you to take Vitamin C supplements separately because both ingredients contain high amounts of ascorbic acid. Ascorbic acid, being acid forming in the blood, will acidify the blood. Ascorbic acid is essential in maintaining healthy connective tissue and is also thought to act as an antioxidant.

      We hope this helped clear things up. We wish you a happy and healthy day!

  2. Though it is a less common method of removing hair

    at skin’s surface, some consumers find it primarily useful for fine hair on legs.

    Braun epilators have captured a share of consumers and reviewers note that epilators bearing the Braun logo tend to win product pricing wars frequently.

  3. Nice article, but humans (along with a handful of animals) cannot synthesize vitamin C, as this sentence seems to suggest:

    "And, of course, vitamin C is essential for collagen production and synthesized in the skin too."

    That is why you get scurvy without vitamin C in your diet. That's all. Thanks.

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