Feeling Tired or Sluggish? You May Be Deficient in the “Energy” Vitamin (Methylcobalamin B12)

By Jonathan Hunsaker

Reading Time: 6 minutes

This article discusses emerging/ongoing science and research. It is intended for general informational purposes only. This content is unrelated to products offered by Organixx and does not contain any representations about the performance of such products.

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Do you ever suffer from chronic fatigue, depression, digestive dysfunction, or joint pain? Did you know that all of these are potential signs of a vitamin B12 deficiency?

You may not realize it… but eating takes a whole lot of work. Sure, it’s easy enough to pick up a morsel of food, chew, and swallow. But it’s what comes next that ultimately determines whether your body derives any benefit from what you’ve just consumed.

Most people are aware that the digestive process is what converts larger food particles into smaller nutrients that the body can use to build muscle, generate energy, and generally keep things running smoothly. But this complex series of chemical reactions only do so if all the necessary cofactors are present.

Often in the modern world, these cofactors aren’t present – which is when problems start to arise. Many people just aren’t eating the well-rounded diets that facilitate healthy digestion and proper nourishment, which leaves them feeling weak, lethargic, and not fully themselves.
If this sounds like you, there’s a good chance that you’re deficient in something nutrition-wise.

If you constantly feel tired, moody, and unable to seize the day like you once could, this could point to a vitamin deficiency – particularly vitamin B12, the “energy” vitamin.

What Is Vitamin B12 and Why Is it Important?

man feeling tired & stressed outAlso known as cobalamin or methylcobalamin, vitamin B12 is a water-soluble nutrient typically found in meat, fish, dairy, and eggs.

Vitamin B12 plays a critical role in regulating:

  • Mood
  • Memory
  • Energy levels
  • Digestion
  • Heart function
  • Skin health
  • Hormone production
  • Homeostasis throughout the body

Signs & Symptoms of a Vitamin B12 Deficiency

Because the body’s entire metabolic structure depends on vitamin B12, this vitamin deficiency can take many forms. Some signs of vitamin B12 deficiency are obvious, while other potential signs of a deficiency in B12 are much more subtle. These can include:

  • chronic fatigue
  • depression
  • digestive dysfunction
  • joint pain

One of the reasons why symptoms of vitamin B12 deficiency can vary dramatically is due to the many ways this nutrient functions at the cellular level. The central nervous system, for instance, relies on vitamin B12 to not only protect against nerve damage but also to facilitate neurotransmitter signaling. It plays a critical role in almost every cognitive function.

Because vitamin B12 also facilitates energy production, deficiency can manifest in several ways, including an inability to stay focused. Some people will feel that they just aren’t as sharp as they used to be, which could mean that they aren’t getting enough B12 in their diet.

Vitamin B12 Works to Support Wellness

At its most basic level, vitamin B12 is responsible for converting homocysteine, a food-based amino acid, into methionine, a sulfur-containing amino acid metabolite that the body uses for countless metabolic processes.

This conversion is often referred to in scientific literature as the methionine cycle, and it’s one of the most critical components of maintaining optimal health.

laboratory-result-of-homocysteine-test-to-test-for-vitamin-b12-deficiencyWhen vitamin B12 is lacking, and homocysteine builds up in the blood, the methionine cycle is deemed broken. This is when disease risk begins to skyrocket [1].

As the primary catalyst in supporting the methionine cycle, vitamin B12 must be present for the body to synthesize proteins and support cellular maintenance and repair.

Vitamin B12 further helps to protect the integrity of DNA and RNA, and the functionality of nerve and brain cells. With an ability to cross the blood-brain barrier, vitamin B12 directly supports the healthy production of serotonin, the mood-regulation molecule that plays a key role in balancing mood and supporting emotional health.

If you experience this vitamin deficiency, your body wouldn’t be able to produce red blood cells, which deliver necessary oxygen to bodily tissues. Your immune system would eventually fail without vitamin B12, which functions as a key ingredient in the manufacture of white blood cells that ward off disease.

Methylcobalamin vs Cyanocobalamin: What Does Your Body Prefer?

One of the leading nutrient deficiencies in the world, vitamin B12 is commonly recommended as a dietary supplement. Unfortunately, the type most often available in supplement form cyanocobalamin isn’t exactly what the body needs to fill this nutritional gap.

While cyanocobalamin isn’t completely useless, the body must exert large amounts of energy to convert it into methylcobalamin B12, the type of vitamin B12 that it prefers.

This conversion process further depletes the body of energy, which is the exact opposite of what you want when your energy stores are already low due to a B12 deficiency.

list-of-different-types-of-vitamin-b12Methylcobalamin is preferable because it contains methyl molecule groups that activate hundreds of necessary chemical reactions throughout the body. These methyl groups aren’t present in cyanocobalamin, which contains cyanide molecules which must undergo major changes to become usable by the body.

As the premiere form of vitamin B12, methylcobalamin bears the stability and bioavailability that cyanocobalamin lacks. It’s the only form of vitamin B12 that’s capable of crossing the blood-brain barrier without any sort of help or pre-conversion.

Methylcobalamin B12’s methyl groups perform several important functions that cyanocobalamin’s cyanide groups cannot, including:

  • Direct stimulation of serotonin production
  • Detoxification of heavy metals, environmental toxins, and other damaging waste products from the body
  • Protection against excitotoxin damage in the brain [2]
  • Neutralization of homocysteine, an excess buildup of which can increase the risk of heart disease, stroke, and sclerosis of the arteries
  • Formation of antioxidant precursors used to create mitochondrial energy

In short, cyanocobalamin is an inferior form of vitamin B12 that just can’t compare to methylcobalamin.

The Best Natural Sources of Methylcobalamin B12

good food sources of vitamin B12So, what are some of the best sources of natural methylcobalamin? One place you won’t find it is in plant-based foods, which is why vegetarians and vegans need to be extra vigilant against vitamin B12 deficiency.

While some forms of seaweed and mushrooms contain similar forms of vitamin B12, the human body is unable to utilize these because they aren’t compatible. They’re often described as being “inactive” forms of vitamin B12 [3].

With that said, animal-based foods are nature’s richest sources of methylcobalamin, though even these can be limited in supply. Excellent natural sources of methylcobalamin include:

  • Crickets
  • Liver
  • Fish
  • Beef and lamb
  • Eggs
  • Chicken
  • Mutton
  • Dairy foods

The National Institutes of Health (NIH) recommend that:

  • children intake between 1.2-1.8 mcg of vitamin B12 per day
  • adults intake between 2.4-2.8 mcg per day [4] 

While this is a relatively small amount compared to other vitamins, it’s not always easy to get this in a normal diet, unless you’re eating a lot of meat and fish, or supplementing with methylcobalamin.

Remember that it’s important to get enough B12 in your diet to help regulate mood, memory, energy levels, digestion, heart function, skin health, hormone production, and homeostasis. 

The latest formula of Organic OrganiGreens is our best yet. In just one simple scoop, add 17 sprouted and fermented superfoods and botanicals, plus probiotics and enzymes, to your daily diet to fill nutritional gaps and support healthy immune function, increased energy and mental clarity, as well as digestion and detoxification processes. Easily mixes in water, smoothies, juices, and recipes, and it also tastes great – even without any added sugars.


Article Summary

  • If you feel tired and lack energy, you could be deficient in methylcobalamin B12 (vitamin B12).

  • B12 plays a critical role in regulating mood, memory, energy levels, digestion, heart function, skin health, hormone production, and homeostasis.

  • B12 converts food-based amino acid into methionine.

  • Methionine activates hundreds of necessary chemical reactions throughout the body.


  1. There is no reason EVER to eat any type of Cricket or other bugs! Humans were not ever made to eat bugs and studies have shown it is BAD for human consumption despite what the crazy, absurd elites on the left would prefer us underlings to eat. THEY never will eat it, because they know better... NEVER will I. I check every label on packaged foods now to avoid it.

    • Hello Dee, Thank you for your interest in our products. Although we do not sell B12 as a stand alone product, we do offer it in our Multi-Vita-Maxx product. It contains 60mcg per dose which provides 2500% of your daily value. You can find out more here: https://shop.organixx.com/products/multi-vita-maxx I hope you decide to give it a try. Have a wonderful day!

  2. I bought 3 containers of Organixx Cricket Super Fuel quite some time ago and would be very interested in replenishing my supply. I especially liked the chocolate flavour. However, I don't see where I can re-order.

    Can you help me?

    • Hi Judy, thanks for your question.

      Like you, we have loved having the Cricket Super Fuel as part of our product family! To quote a caring friend of us all, “ How lucky were we to have something that makes saying goodbye so hard.” (Winnie the Pooh)

      But as can happen in business, change occurs for all the right reasons. With that in mind, Organixx has made the decision to discontinue the Cricket Super Fuel. We are thankful for your interest in our products!

      At this time, there are no plans to offer this product again. However, we have an amazing alternative for you that we think you’ll love!

      We recommend our Organic Bone Broth Protein offered in Pure, Chocolate and Vanilla flavors! Like Cricket Fuel, our Organic Bone Broth Protein is tested to be free of GMO’s, supports your immunity and promotes good digestive health.

      We hope this helps. Thank you so much for your trust and support in Organixx!

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