Feeling Tired or Sluggish? You May Be Deficient in the “Energy” Vitamin (Methylcobalamin B12)

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Do you ever suffer from chronic fatigue, depression, digestive dysfunction, or joint pain? Did you know that all of these are potential signs of a vitamin B12 deficiency?

You may not realize it… but eating takes a whole lot of work. Sure, it’s easy enough to pick up a morsel of food, chew, and swallow. But it’s what comes next that ultimately determines whether your body derives any benefit from what you’ve just consumed.

Most people are aware that the digestive process is what converts larger food particles into smaller nutrients that the body can use to build muscle, generate energy, and generally keep things running smoothly. But this complex series of chemical reactions only do so if all the necessary cofactors are present.

Often in the modern world, these cofactors aren’t present – which is when problems start to arise. Many people just aren’t eating the well-rounded diets that facilitate healthy digestion and proper nourishment, which leaves them feeling weak, lethargic, and not fully themselves.
If this sounds like you, there’s a good chance that you’re deficient in something nutrition-wise.

If you constantly feel tired, moody, and unable to seize the day like you once could, this could point to a vitamin deficiency – particularly vitamin B12, the “energy” vitamin.

What Is Vitamin B12 and Why Is it Important?

man feeling tired & stressed outAlso known as cobalamin or methylcobalamin, vitamin B12 is a water-soluble nutrient typically found in meat, fish, dairy, and eggs.

Vitamin B12 plays a critical role in regulating:

  • Mood
  • Memory
  • Energy levels
  • Digestion
  • Heart function
  • Skin health
  • Hormone production
  • Homeostasis throughout the body

Signs & Symptoms of a Vitamin B12 Deficiency

Because the body’s entire metabolic structure depends on vitamin B12, this vitamin deficiency can take many forms. Some signs of vitamin B12 deficiency are obvious, while other potential signs of a deficiency in B12 are much more subtle. These can include:

  • chronic fatigue
  • depression
  • digestive dysfunction
  • joint pain

One of the reasons why symptoms of vitamin B12 deficiency can vary dramatically is due to the many ways this nutrient functions at the cellular level. The central nervous system, for instance, relies on vitamin B12 to not only protect against nerve damage but also to facilitate neurotransmitter signaling. It plays a critical role in almost every cognitive function.

Because vitamin B12 also facilitates energy production, deficiency can manifest in several ways, including an inability to stay focused. Some people will feel that they just aren’t as sharp as they used to be, which could mean that they aren’t getting enough B12 in their diet.

Vitamin B12 Works to Support Wellness

At its most basic level, vitamin B12 is responsible for converting homocysteine, a food-based amino acid, into methionine, a sulfur-containing amino acid metabolite that the body uses for countless metabolic processes.

This conversion is often referred to in scientific literature as the methionine cycle, and it’s one of the most critical components of maintaining optimal health.

laboratory-result-of-homocysteine-test-to-test-for-vitamin-b12-deficiencyWhen vitamin B12 is lacking, and homocysteine builds up in the blood, the methionine cycle is deemed broken. This is when disease risk begins to skyrocket [1].

As the primary catalyst in supporting the methionine cycle, vitamin B12 must be present for the body to synthesize proteins and support cellular maintenance and repair.

Vitamin B12 further helps to protect the integrity of DNA and RNA, and the functionality of nerve and brain cells. With an ability to cross the blood-brain barrier, vitamin B12 directly supports the healthy production of serotonin, the mood-regulation molecule that plays a key role in balancing mood and supporting emotional health.

If you experience this vitamin deficiency, your body wouldn’t be able to produce red blood cells, which deliver necessary oxygen to bodily tissues. Your immune system would eventually fail without vitamin B12, which functions as a key ingredient in the manufacture of white blood cells that ward off disease.

Methylcobalamin vs Cyanocobalamin: What Does Your Body Prefer?

One of the leading nutrient deficiencies in the world, vitamin B12 is commonly recommended as a dietary supplement. Unfortunately, the type most often available in supplement form cyanocobalamin isn’t exactly what the body needs to fill this nutritional gap.

While cyanocobalamin isn’t completely useless, the body must exert large amounts of energy to convert it into methylcobalamin B12, the type of vitamin B12 that it prefers.

This conversion process further depletes the body of energy, which is the exact opposite of what you want when your energy stores are already low due to a B12 deficiency.

list-of-different-types-of-vitamin-b12Methylcobalamin is preferable because it contains methyl molecule groups that activate hundreds of necessary chemical reactions throughout the body. These methyl groups aren’t present in cyanocobalamin, which contains cyanide molecules which must undergo major changes to become usable by the body.

As the premiere form of vitamin B12, methylcobalamin bears the stability and bioavailability that cyanocobalamin lacks. It’s the only form of vitamin B12 that’s capable of crossing the blood-brain barrier without any sort of help or pre-conversion.

Methylcobalamin B12’s methyl groups perform several important functions that cyanocobalamin’s cyanide groups cannot, including:

  • Direct stimulation of serotonin production
  • Detoxification of heavy metals, environmental toxins, and other damaging waste products from the body
  • Protection against excitotoxin damage in the brain [2]
  • Neutralization of homocysteine, an excess buildup of which can increase the risk of heart disease, stroke, and sclerosis of the arteries
  • Formation of antioxidant precursors used to create mitochondrial energy

In short, cyanocobalamin is an inferior form of vitamin B12 that just can’t compare to methylcobalamin.

The Best Natural Sources of Methylcobalamin B12

good food sources of vitamin B12So, what are some of the best sources of natural methylcobalamin? One place you won’t find it is in plant-based foods, which is why vegetarians and vegans need to be extra vigilant against vitamin B12 deficiency.

While some forms of seaweed and mushrooms contain similar forms of vitamin B12, the human body is unable to utilize these because they aren’t compatible. They’re often described as being “inactive” forms of vitamin B12 [3].

With that said, animal-based foods are nature’s richest sources of methylcobalamin, though even these can be limited in supply. Excellent natural sources of methylcobalamin include:

  • Crickets
  • Liver
  • Fish
  • Beef and lamb
  • Eggs
  • Chicken
  • Mutton
  • Dairy foods

The National Institutes of Health (NIH) recommend that:

  • children intake between 1.2-1.8 mcg of vitamin B12 per day
  • adults intake between 2.4-2.8 mcg per day [4] 

While this is a relatively small amount compared to other vitamins, it’s not always easy to get this in a normal diet, unless you’re eating a lot of meat and fish, or supplementing with methylcobalamin.

Remember that it’s important to get enough B12 in your diet to help regulate mood, memory, energy levels, digestion, heart function, skin health, hormone production, and homeostasis. 

Article Summary

  • If you feel tired and lack energy, you could be deficient in methylcobalamin B12 (vitamin B12).

  • B12 plays a critical role in regulating mood, memory, energy levels, digestion, heart function, skin health, hormone production, and homeostasis.

  • B12 converts food-based amino acid into methionine.

  • Methionine activates hundreds of necessary chemical reactions throughout the body.

Reader Interactions


  1. Really Ty! CRICKETS.? LOL Were they chosen plate covered. Well guess if I had chocolate covered ants and grasshoppers I could et cricket powder. Hmmm let me think.

    • Yes, Mary. Ty and the team fully believe that crickets are great source of Vitamin B12. We hope you get to try this soon and let us know how you feel about it!

  2. I’d like to know how much caffeine is in the chocolate cricket powder per the 1 day serving?

  3. How do they prepare the crickets for this powder? Have to say, I’ve always been skeptical about the degree of sanitation, and then how good cleaning might affect potency.

    • Hi Kathy. The crickets used are housed separately from birth to processing in order to ensure they remain organic. The Crickets are fed a diet of organic vegetables in order to ensure that our Cricket Super Fuel remains organic and gluten free.

  4. I started taking this in the mid 1990’s along with B6. Having some trouble with wrist and coffee cup fell out of hand without knowing it did. My Mom worked at the hospital so she talked to some of the doctors and they suggested for me to take both. Job I had consists of doing the same motions all day with my wrist.
    I order both of these online since the mid 1990’s and it has helped my wrist where it doesn’t hurt at all any more. If I back off of it for a few days then wrist starts to act up again which I noticed just recently so I am taking it everyday. Over the last few years my B12 levels are high so that is why I thought to take it every couple of days. I see I can’t.
    I am probably buying the wrong kind according to this article. Everywhere I look it is cyanocobalamin, even when I buy online it’s the same.

  5. I have the Mfthr gene mutation so dr gave me injectable b12 every time I get the bloods tested my b12 is over 2,500 I was never out of the normal range before the injections. Any thoughts

    • Hello, Rose. Organixx cannot diagnose, treat or give you advice regarding your health and individual use of our products. If you have questions regarding individual use of our product, please consult with a physician or specialist.

  6. Have not eaten animals for about 35 years and have recently turned 85. Still totally self-supporting, it can’t have affected me too badly. But I am concerned about lack of B12 and must find some way around it. However, I don’t plan to add crickets my diet.
    Do continue your research.
    All the best.

    • We respect that Mairead. Our team will continue to develop and research products that will help people like you in becoming healthier. Congratulations on turning 85!

    • mairead ross global healing centre does a product called vegan safe Really good talk on youtube xx

    • I would like to know that as well. I am vegetarian for 16 years. The only way I get sufficient B12 is with an injection but it doesn’t seem to be work g anymore

  7. I have been having 10 C of 12 B injection since a blood test 2 years ago starting with a large boost to begin with as my Doctor said my body was not retaining the vitamin which often happens at 50’s & 6o’s yrs on now I have I have one injection every 3 months prescribed by my Doctor I still get tired in the day is there any further supplement I should be taking ?

    • Hi Robert, thank you for sharing your story. We at Organixx suggest you consult with your primary healthcare practitioner related to your own unique health needs and health challenges.

  8. Thank you Dr Bolinger from Dar es Salaam Tanzania.
    Noted use of vitamin b12. Beyond 60 years it is usual to Be tired from many facts. How does it support Erection Dysfunction?

    • Hello Faustine, if you have questions regarding individual use of our product, please consult with a physician or specialist. We wish you the best!

  9. This is very interesting. I think we try to find all sorts of reasons for feeling tired but, this has made me look at it differently. I will certainly eat what has been listed and, see if there is an improvement.

    • Hi Ronnie! We’re happy that you found this information useful and we’d love to hear an update soon!

  10. Good article.. But…we are vegan and consume non of the above. We take vit b12
    In liquid form. What is your opinion on the B12 shots?

    • Hi Lynn! We’re glad you liked the article. Organixx cannot diagnose, treat, or give you advice regarding your health and individual use of products. We recommend speaking with a health professional about B12 shots.

  11. Are you sure you have your measurements correct , for example mcg versus mg. The recommended dosages seem very low.

  12. Crickets! Interesting! Well, John the Baptist ate locusts; so, I shouldn’t be surprised that crickets are a good source of nutrition.

    • Hello Xuan, we understand your concern. Everyone is different and everyone’s body reacts differently to different products. We highly suggest speaking with a medical professional before starting any new supplements or health regimes. Although, individuals with shellfish allergies may be allergic to crickets. If you are allergic to shellfish or are concerned you may be allergic to crickets, do not use Cricket Super Fuel.

  13. I have seen some specials on the Travel channel and food channels talking about Dried and ground crickets for making all types of foods that are rich in proteins and vitamins as a way to help fight world hunger. And that for many parts of the world insects are a huge part of their diet. Most of the western world is not quite ready to accept this just yet. Just the thought is a bit much for them, but if proven tasty they can eventually get past this.

    • We agree, Emir. Eating crickets is not new in the other parts of the world. Are you keen on trying out the Cricket Super Fuel? Let us know how you liked it!

  14. I can’t tell how many ounces is in a canister. Also, what is the recommended serving size? Thank you.

    • Thank you for the appreciation, Vangie. We hope you’ll give Cricket Super Fuel a try, which is a great source of Vit. B12!

    • After reading the article, I believe I am deficient in Vit. B12 as well. I have finished chemo treatments for about 6 months now and brain radiation for about 1.5 mths now. I feel worse now than I did throughout my eight months of treatments. About 3 weeks ago, about 1 month after my last radiation treatment, I started to feel extremely tired, high anxiety, and extreme weakness in my legs especially and dizziness every day all day unless im sitting. I will definitely try the Vit. B12

  15. Are there any othersources of B12 besides crickets that you recommend….The Bible forbids eating these types of creatures….

    • Hi Elroy. Our team continues to research and to formulate products that can accommodate all customers with different health needs. Please continue supporting Organixx and look out for the new products we are releasing!

    • Hello Elroy,
      I’m curious if you could give me the scripture verses that you said the Bible forbids us from eating these types of creatures? Thank you for your help!

  16. Very interesting, informative. some of it reminding me of things I had forgotten I knew. I would have liked to see — maybe it’s there but i missed it — a hint regarding a reasonable dosis of the supplement.
    Something else about the piece that I appreciate — its having been composed in what I like to call CLEAN, LEAN English.

    • Sorry you feel that way, Debra. You may sign-up for our newsletter or follow us on our social media accounts to be informed about discounts and sales we are having!

  17. Since I am supposed to be giving myself B-12 shots but stopped due to negative info I heard about their ingredients, I was so excited about this product until I saw that it only comes in powered form. I reallly love & trust your amazing line of products but am so disappointed that powdered is all that’s available. What are the chances you’ll be putting this into pill or capsule form soon?

    • Hello Lynn, we understand where you are coming from. Our team is very open to suggestions like yours and we will make sure to forward your concerns to the right department.

      • Just buy methylcobalamin in pill form, jarrow formulas have some b12 in pill form. 1000 mcg.
        No need to start eating crickets just to get your methylcobalamin.

  18. like this article.
    Been on B12 shots for months now. It does work having enough B12 in the body.I’m fighting with IBD and the collateral damage of UC ( ulcerative colitis ). one of them is trace mineral issues and not using B12 correctly.
    just a note here, if your “intrinsic factor” located in the stomach is not functioning right, or is low, or has inhibited fiction then a B12 supplement will likely not work well for you. will need to get shots. As stated above in the article summary above, these things and more, lwill not fiction well. every body is different but in the end the results will be the same at different severity’s.
    great article !
    keep up the good work:)

    • That’s really interesting, Brian. Thank you for sharing and for taking the time to leave feedback!

  19. Thank you for an interesting read. Not sure crickets will go down easily. However, I have been taking a pharmaceutical ubiquinone for years and it is amazing. I am going to look to add Methylcobalamin one way or another to make sure I get enough.

    • Hi Kay! I know crickets can seem daunting, but fortunately our Cricket Super Fuel comes in two great flavors and doesn’t feel like eating crickets at all. Let us know if you try it!

  20. I, along with a high percentage of the population, take Metformin for Diabetes 2.
    The label included in each packet advises that Metformin depletes B 12 in our bodies.
    I solve that problem by taking the B 12 that dissolves under the tongue (sublingual),
    & it works a treat 🙂

    • Hi Kimberly, thank you for sharing that with us. We do understand why you’ll have to take a pass at our Cricket Super Fuel for being vegetarian. We totally respect your diet and we hope you can check our other supplements that are not only vegetarian and vegan-friendly, but are also USDA Certified Organic!

      Kindly use the following links to browse and learn more about them:

      We wish you the best in your health journey!

  21. I bought 3 containers of Organixx Cricket Super Fuel quite some time ago and would be very interested in replenishing my supply. I especially liked the chocolate flavour. However, I don’t see where I can re-order.
    Can you help me?

    • Hi Judy, thanks for your question.

      Like you, we have loved having the Cricket Super Fuel as part of our product family! To quote a caring friend of us all, “ How lucky were we to have something that makes saying goodbye so hard.” (Winnie the Pooh)

      But as can happen in business, change occurs for all the right reasons. With that in mind, Organixx has made the decision to discontinue the Cricket Super Fuel. We are thankful for your interest in our products!

      At this time, there are no plans to offer this product again. However, we have an amazing alternative for you that we think you’ll love!

      We recommend our Organic Bone Broth Protein offered in Pure, Chocolate and Vanilla flavors! Like Cricket Fuel, our Organic Bone Broth Protein is tested to be free of GMO’s, supports your immunity and promotes good digestive health. To learn more about our Organic Bone Broth please see the product page on our website: https://shop.organixx.com/collections/all-products/products/organic-bone-broth-protein.

      We hope this helps. Thank you so much for your trust and support in Organixx!

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